Professor Albert Stuart Reece and Clinical Research

As well as working with patients clinically Dr Reece is also a Professor of Medicine at the University of Western Australia and the Edith Cowan University which are both near Perth in Western Australia.

 

For many years Dr Reece has published clinical and epidemiological research and reviews of basic science relevant to drug use and exploring the health implications of the known harms and risks of drug use and drug dependency.  This body of work is ethically approved by various Human Research Ethics Research Committees around the country.

This extensive research agenda continues to grow as new papers are being added to the list all the time.  The current list is noted below which will be periodically updated.

The work has several major themes:

  • Aggregated (de-identified and confidential) clinical reviews of trends comparing drug dependent patients with those who are not drug dependent;

  • The relationship of many drugs of dependence to accelerate cardiovascular ageing and and accelerated ageing of the whole human body;

  • Risks associated with cannabis use especially genotoxicity – expressed clinically in birth defects and cancers – and neurotoxicity – expressed clinically in autism and mental illness.

 

At present Dr Reece is using advanced statistical techniques in R to conduct space-time analyses and look at the formal statistical pathways of causal inference – showing that relationships are not just associations but actually causal – in various large national USA datasets using the advanced software data analysis program called “R” which is freely available online.

PUBLICATIONS IN PRINT

 

  1. Adams P.C., Reece A.S., Powell L.W., Halliday J. W. (1989) Hepatic Iron in the Control of Iron Absorption in the Rat Liver Transplantation Model.  Transplantation 48 (1) 19-21.

  2. Lord R.S.A., Graham A.R., Shanahan M.X., Chang V., Reece A.S., Farnsworth A.E., Esmore D.S., Pratt P., (1986) “Rationale for Simultaneous Carotid Endarterectomy and Aorta-coronary Bypass” Ann. Vasc. Surg. 1(2) 201-7.

  3. Reece A.S., Lynch S.V., Lord R.S.A., Yeates M.G., Eberl S., (1987) “Rat Orthotopic Liver Transplantation: Technique and Initial Studies”. Abstract in A.N.Z. J. Surg. 57 (4) 265.

  4. Adams P.C., Reece A.S., Powell L.W., Halliday J.W. (1988) “Hepatic Iron Stores in the Control of Iron Absorption in the Rat Liver Transplantation Model”. Abstract in the Proceedings of the Haematology Society of Australasia. A.N.Z. J. Med. 18 (3) 435.

  5. Adams P.C., Reece A.S., Powell A.S., Halliday J.W., (1989) Does the Hepatocyte Regulate Iron Absorption?” Abstract in the Proceedings of the Gastroenterological Society of Australia, Perth, April 1989.

  6. Tan K.C., Malcolm G.P., Reece A.S., Howard E.R. (1991) “The Surgical Anatomy of Donor Right Trisegmentectomy Before Orthotopic Liver Transplantation in Children”. Brit. J. Surg. 78 (7) 805-808.

  7. Reece A.S.  “Breast Cancer and COCP.”  Aust Fam Physician. 2000 May;29(5):406-7.

  8. Reece A.S.  “Alcohol Licensing Data.”  Med J Aust. 1998 Nov       2;169(9):503-4.

  9. Reece A.S.  “Hepatitis C--a Current Perspective.”  Aust Fam Physician. 1995        Aug;24(8):1577-8.

  10. Heaton ND, Reece AS, Tan KC.  “Graft-Versus-Host Disease Following   Liver Transplantation.”  J R Soc Med. 1992 Jun;85(6):313-4.

  11. Reece S.   “Rapid Opioid Detoxification in Australia.”  Acad Emerg Med. 2002 Sep; 9(9):960-2.  PubMed ID 12208687.  DOI: 10.1197/aemj.9.9.960  http://onlinelibrary.wiley.com/doi/10.1197/aemj.9.9.960/abstract

  12. Reece A.S.  “Naltrexone Implants Set to Supercede HM”  Letter to British Medical Journal January 2005 330 (7483): 147.  (“HM” stands for “Harm minimization.”).  Published 23/09/2004.  PMID: 15649939. http://www.bmj.com/content/330/7483/147.1.long doi: https://doi.org/10.1136/bmj.330.7483.147 

  13. G.K. Hulse, D.E. Arnold-Reed and H. Ngo, S Reece., “Naltrexone Implants in the Treatment of Heroin Addiction.”  Ed: McKenna C.R. (2007)  In: Trends in Substance Abuse Research, Nova Publications, New York.  Chapter 3, pp71-88. ISBN: 1-60021-368-5.  https://www.novapublishers.com/catalog/product_info.php?products_id=4698

  14. Reece A.S.  “Accelerated Hair Graying in Opiate Addicts” , Archives of Dermatology, 2007; 143 (1): 116-118.  PMID: 17224556.  DOI: 10.1001/archderm.143.1.116https://jamanetwork.com/journals/jamadermatology/article-abstract/410418?redirect=true

  15. Reece A.S.  “Dentition of Addiction in Queensland:  Poor Dental Status and Major Contributing Drugs.”  Aust. Dent. J.  2007. 52(2): 144-149.  PMID: 17687962.  DOI: 10.1111/j.1834-7819.2007.tb00480.x http://onlinelibrary.wiley.com/doi/10.1111/j.1834-7819.2007.tb00480.x/abstract

  16. Reece A.S.  “Lifetime prevalence of cervical neoplasia in an addiction clinic”  Australian and New Zealand Journal of Obstetrics and Gynaecology 2007; 47: 419-423.  PMID: 17877603.  DOI: 10.1111/j.1479-828X.2007.00769.x http://onlinelibrary.wiley.com/doi/10.1111/j.1479-828X.2007.00769.x/abstract

  17. Reece A.S., Davidson P.  “Deficit of circulating stem - progenitor cells in opiate addiction maintenance:  pilot study.”  Subst Abuse Treat Preven. Policy 2007; 2 (1): 19-25.  PMID: 1765060.  https://doi.org/10.1186/1747-597X-2-19 https://substanceabusepolicy.biomedcentral.com/articles/10.1186/1747-597X-2-19

  18. Reece A.S. “Evidence of Accelerated Ageing in Clinical Drug Addiction from Immune, Hepatic and Metabolic Biomarkers.”  Immunity and Ageing 2007; 4 (1): 6-12.  PMID: 17892544.  https://doi.org/10.1186/1742-4933-4-6 https://immunityageing.biomedcentral.com/articles/10.1186/1742-4933-4-6

  19. Reece A.S.  “When Harm minimization is Not Harm Minimization – Australia as a Case Study”  Journal of Global Drug Policy 1(4), December 2007. http://www.globaldrugpolicy.org/Issues/Vol%201%20Issue%204/When%20Harm%20minimization.pdf

  20. Reece A.S.  “Psychosocial and treatment correlates of opiate free success in a clinical  review of a naltrexone implant program.”  Subs Abuse Treatment Prevention Policy and Practice 2007; 2: 35-47.  PMID: 18063213. DOI:10.1186/1747-597X-2-35. https://substanceabusepolicy.biomedcentral.com/articles/10.1186/1747-597X-2-35

  21. Reece A.S.  “Clinical Implications Of Addiction Related Immunosuppression.”  J. Infection.  2008; 56(6) 437-445.  PMID: 18440646. DOI: http://dx.doi.org/10.1016/j.jinf.2008.03.003 https://linkinghub.elsevier.com/retrieve/pii/S0163-4453(08)00123-0

  22. Reece A.S.   “Respiratory Effects of Cannabis.”  Drug Watch International Newsletter 22/12/2007. 12(2): 1.  http://www.drugwatch.org/component/search/?searchword=respiratory%20effects%20cannabis&ordering=newest&searchphrase=all&limit=20

  23. Reece A.S. “Chronology And Patterns Of Psychiatric Morbidity In Substance Dependent And Medical Patients”  Australasian Psychiatry 2009; 17 (2) 170-171.  April.  doi:  10.1177/103985620901700203. http://journals.sagepub.com/doi/10.1177/103985620901700203

  24. Reece A.S.  “Response to Aldington: Cannabis and Lung Cancer.”  Letter in European Respiratory Journal, 2008; 32 (1): 238-239.  July.  PMID: 18591344. doi: 10.1183/09031936.00024408. http://erj.ersjournals.com/content/32/1/238.long

  25. Reece A.S.  “Experience of road and other trauma by the substance dependent patient: A survey report.”  Subs. Abuse Prevention, Treatment and Policy, Accepted 2008; 3: 10-22.  PMID: 18454868. https://doi.org/10.1186/1747-597X-3-10 https://substanceabusepolicy.biomedcentral.com/articles/10.1186/1747-597X-3-10

  26. Reece A.S.  “Cannabis as a Cause of Giant Cystic Lung Disease”  Q Journal of Medicine, 2008; 101(6): 503.  PMID: 18375474. https://doi.org/10.1093/qjmed/hcn040 https://watermark.silverchair.com /hcn040.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAagwggGkBgkqhkiG9w0BBwagggGVMIIBkQIBADCCAYoGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMiEVKruEaqMsiWpZ9AgEQgIIBW8V7CQMiGsQ5aRZWj3lyBPZsCs8n2rikZrVf-8QENNoM4hSs4nyrotLCQRQ3DPsogFQk_uv3L5Lr1wIa4bJHm49PfYMmBaPeBqNH5Fk0nup4dRFTgwhW9S8NDgPf5-VF9EphZVzXQ4Ls6IIG5OFLEgkrUiY9TapsR5TBl7f99ip4YZld9XvwrRakHS3q9CLVN5C-1LoFrcHZ8XwIX6smUtaL82P9R2wN3xjt77XkKC-UDxqQUGDAL-qPWAv58WOaB-g2p14KAjWzbNFhguTBsplZkcJD-Tpv9uP5vJvM7iuTD-GZcFfc5udQPJkBjMXAmQ1wkPukD3egtifa0I64FBjaF305KMziFDi15kcaJE-VaB6tNCZ96w-hpXt6jdUziA3GyW1MFYqyWsyl2A2qHVB-LwoHh_DU3BlCzml5TFgY4bbz6NQWuMb1tKeSUfLBxDsShFld-K9oiJEx

  27. Reece A.S.  "Chronic viral hepatitis is a significant contributor to the immunosenescent phenotype of parenteral drug addiction"  Addiction Biology 2009; 14 (2): 214-226.  PMID: 18811680. DOI: 10.1111/j.1369-1600.2008.00123.x http://onlinelibrary.wiley.com/doi/10.1111/j.1369-1600.2008.00123.x/abstract;jsessionid=CD43882532F5BB2FEC2D1E632CF667E9.f02t04

  28. Reece A.S.  “An Intriguing Association Between Dental and Mental Pathology in Addicted and Control Subjects: A Cross-sectional survey.”  Brit. Dental J., part of the Nature Group.  2008; 205(11): E22-E30.  PMID: 18953330.  ePublished  24th October 2008. DOI: 10.1038/sj.bdj.2008.932    https://www.nature.com/articles/sj.bdj.2008.932

  29. Reece A.S. "Summary of: An Intriguing Association Between Dental and Mental Pathology in Addicted and Control Subjects: A Cross-sectional survey" Brit. Dental J. 2008; 205(11): 598-599.   doi:10.1038/sj.bdj.2008.1035.  ePublished  13th December 2008. https://www.nature.com/articles/sj.bdj.2008.1035

  30. Reece A.S.  “Appetitive and Addictive Factors Pertinent to Neuroscience Studies of Sexuality”  Proceedings of the National Academy of Sciences, USA.  2008;  105 (46): E86.  PMID 19004795.  DOI: 10.1073/pnas.0807879105 http://www.pnas.org/content/105/46/E86.long   

  31. Reece A.S. “Chronic Ulcers due to Injection of Substances: Healing aided by Naltrexone.”  Archives of Dermatology, 2009 145(4): 375-377.  PMID: 19380658.  doi:10.1001/archdermatol.2009.4 https://jamanetwork.com/journals/jamadermatology/fullarticle/711968

  32. Reece A.S.  “Haemodynamic Changes in Acute Opiate Withdrawal” Q Journal of Medicine, 2009; 102: 357.  PMID: 19028746.  https://doi.org/10.1093/qjmed/hcn151 https://academic.oup.com/qjmed/article/102/5/357/1603059

  33. Reece A.S. “Improved Parameters of Metabolic Glycaemic and Immune Function and Arterial Stiffness with Naltrexone Implant Therapy.”  British Medical Journal Case Reports, 2009; 2009:bcr0820080799.  Published online 14/04/2009, doi: 10.1136/bcr.08.2008.0799.  PMID: 21687046.  http://casereports.bmj.com/content/2009/bcr.08.2008.0799.long

  34. Reece A.S.  “Deterioration of Indices of Aortic Augmentation and Vascular Age Predate Major Cardiac Events and Interact with Opiate Dependence”  International Journal of Cardiology  Published Online 26/03/2009, DOI: 10.1016/j.ijcard.2009.03.015  PMID: 19327850.   149 (1): e8-e11. http://www.internationaljournalofcardiology.com/article/S0167-5273(09)00254-X/fulltext

  35. Reece A.S.  “Cutting the Gordian Knot of Drug Addiction Confusion: Strategy of Seduction vs. Seduction of Strategy”  J Global Drug Policy.  2009; 2(4) http://www.globaldrugpolicy.org/Issues/Vol%202%20Issue%204/Cutting%20The%20Gordian%20Knot.pdf    . Also   http://braha.com.br/us/wp-content/uploads/2012/06/CUTTING_THE_GORDIAN_KNOT_OF_DRUG_ADDICTION_CONFUSION.pdf    20pp.

  36. Reece A.S.  “Severe Multisystem Dysfunction in a case of high level exposure to smoked cannabis”  Br. Medical Journal - Case Reports.  Published online 2nd September 2009; 2009. pii: bcr08.2008.0798  doi: 10.1136/bcr.08.2008.0798  PMID: 21887157.  http://casereports.bmj.com/content/2009/bcr.08.2008.0798.long

  37. Reece A.S. "Dental Health in Addiction"  Australian Dental Journal, 2009; 54(2): 185-186.  21st May 2009.  doi: 10.1111/j.1834-7819.2009.01116_7.x  PMID: 19473171.  http://onlinelibrary.wiley.com/doi/10.1111/j.1834-7819.2009.01116_7.x/abstract;jsessionid=432C2E23859428AC41BF2FB28198317D.f01t03

  38. Reece A.S.  "Comparative Treatment and Mortality Correlates and Adverse Event Profile of Implant Naltrexone and Sublingual Buprenorphine."  Journal of Substance Abuse Treatment 2009; 37(3): 256-265.  PMID: 19394789. DOI: 10.1016/j.jsat.2009.03.008 http://www.journalofsubstanceabusetreatment.com/article/S0740-5472(09)00028-2/fulltext

  39. Reece A.S.  “Chronic Toxicology of Cannabis”  Clinical Toxicology, 2009; 47(6): 517-524.  PMID: 19586351.  DOI:10.1080/15563650903074507 http://www.tandfonline.com/doi/abs/10.1080/15563650903074507?journalCode=ictx20 

  40. Reece A.S.  Letter: Response to Oviedo-Joekes.  “Diacetylmorphine versus methadone for opioid addiction”  New England Journal of Medicine. 2009; 361(22): 2194-5.  PMID: 19950413.  DOI: 10.1056/NEJMc0908720 http://www.nejm.org/doi/pdf/10.1056/NEJMc0908720

  41. Reece A.S.  “Favourable Mortality Profile of Naltrexone Implants for Opiate Addiction – A Clinical Audit”  Journal of Addictive Diseases 2010; 29(1): 30-50.  PMID: 20390697.    DOI:  10.1080/10550880903435988 https://www.researchgate.net/profile/Albert_Reece/publication/43135694_Favorable_Mortality_Profile_of_Naltrexone_Implants_for_Opiate_Addiction/links/0deec52f3286f56085000000/Favorable-Mortality-Profile-of-Naltrexone-Implants-for-Opiate-Addiction.pdf

  42. Reece A.S.  “Deterioration of Indices of Aortic Augmentation and Vascular Age Predate Cardiac Events and Interact with Opiate Dependence”  Int. J. Cardiol.  Accepted 26/05/2010, 149 (1): e8-e11.  PMID: 19327850. DOI: 10.1016/j.ijcard.2009.03.015.  http://www.internationaljournalofcardiology.com/article/S0167-5273(09)00254-X/fulltext

  43. Reece A.S. “Clinical Safety of 1500mg Oral Naltrexone Overdose” British Medical Journal - Case Reports, 2010 Sep 7;2010. pii: bcr0420102871. PMID: 22778191.  DOI:  10.1136/bcr.04.2010.2871 http://casereports.bmj.com/content/2010/bcr.04.2010.2871.full

  44. Reece A.S. “Chronic Immune Stimulation as a Contributing Cause of Chronic Disease in Opiate Addiction Including Multi-System Ageing”  Medical Hypotheses, 2010, 75 (6), 613-619.  PMID: 20800362. DOI: 10.1016/j.mehy.2010.07.047  http://www.medical-hypotheses.com/article/S0306-9877(10)00294-X/fulltext

  45. Reece A.S. “Hypothalamic Opioid – Melanocortin Appetitive Balance and Addictive Craving”.  Medical Hypotheses, 2011; 76 (1) 132-137.  PMID: 20923200.  DOI: 10.1016/j.mehy.2010.09.002 http://www.medical-hypotheses.com/article/S0306-9877(10)00356-7/fulltext

  46. Reece A.S.  “Resolving the Opiate Policy Paradox: Depot Naltrexone May Provide a Bridge Across High Risk Early Opiate Sobriety.”  British Medical Journal Letter, 2010; 341:c3172.  Published 29/08/2010,  doi: http://dx.doi.org/10.1136/bmj.c3172  http://www.bmj.com/rapid-response/2011/11/02/resolving-opiate-policy-paradox-depot-naltrexone-may-provide-bridge-across   

  47. Reece A.S.  “Giant Cystic Lung Disease With Mediastinal Compression In A Short Term Heavy Cannabis Smoker”  British Medical Journal – Case Reports.  Accepted 4/10/2010.   Published 2/02/2011.   PMID: 22714596. DOI: 10.1136/bcr.04.2010.2934 http://casereports.bmj.com/content/2011/bcr.04.2010.2934.long

  48. Reece A.S., Tashkin D.  “Discussion on Poiseuille’s Law in Cannabis Related Giant Cystic Lung Disease.”  British Medical Journal – Case Reports.  Accepted 18/10/2010.   bcr.04.2010.2934.R2.  file:///D:/1ASReece/Research/2010%20Res/O'Connell%20K%20CR/re%20BMJ%20Case%20Reports%20-%20Decision%20on%20Manuscript%20ID%20bcr.04.2010.2934.R1%20(Finalization%20of%20Dr%20Reece's%20report)%20-%20Acceptance.htm

  49. Reece A.S.  “Differing Age Related Trajectories of Dysfunction in Several Organ Systems in Opiate Dependence”  Aging Clin. Experimental Research 2012; 24 (1): 85-96.  PMID: 21339699.  doi: 10.3275/7518 ePub 21/02/2012. https://link.springer.com/article/10.3275/7518

  50. Reece A.S. “Relative and Age Dependent Stimulation of Soluble and Cellular Immunity in Opiate Dependence”  Journal of Addiction  Medicine  Accepted 5/07/2011. 6 (1) 10-17.  PMID: 21918466. DOI: 10.1097/ADM.0b013e31822c3bf4   https://insights.ovid.com/pubmed?pmid=21918466

  51. Christian G., Pike G., Santamaria J., Reece S., DuPont R., Mangham C.  “Overdose Deaths and Vancouver’s Supervised Injection Facility.”  Lancet (2012)  January 14; 379 (9811): 117.  PMID: 22243818.  doi: 10.1016/S0140-6736(12)60054-3    http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673612600543.pdf?id=baak2z5Qpf52W4qvqkuzu

  52. Baxter J., Baker H.M., Reece S.  “The Use of Cannabis for Medical Purposes.”  J Global Drug Policy (2013) 7 (1) Spring 2013. http://globaldrugpolicy.org/Issues/Vol%207%20Issue%201/The%20Use%20of%20Cannabis%20for%20Medical%20Purposes%20sm.pdf   http://research-repository.uwa.edu.au/en/publications/the-use-of-cannabis-for-medical-purposes(d7790bd9-1e0e-42ac-8ceb-e5a7326d67fb)/export.html

  53. Reece A.S. “Manifold Implications of Forgotten Hyperglycaemia in Clinical Opiate Dependence”  Accepted Drug and Chemical Toxicology (2013) 36 (1) 55-66.  PMID: 22313373.  doi: 10.3109/01480545.2011.649286   ePub 8/02/2012. http://www.tandfonline.com/doi/abs/10.3109/01480545.2011.649286?journalCode=idct20

  54. Reece A.S.,  “High Sensitivity CRP in Opiate Addiction: Relative and Age-Dependent Elevations” Cardiovascular Toxicology.  (2012) 12  (2) 149-157.  PMID: 22297435.  doi: 10.1007/s12012-012-9154-2. https://link.springer.com/article/10.1007%2Fs12012-012-9154-2

  55. Reece A.S.  “What’s Wrong with Medicare”  Commentary on Professional Services Review in Australia.  Accepted Medical Journal of Australia, Published 20th February 2012.  196 (3): 170.  PMID: 22451969. DOI: 10.5694/mja12.10099 https://www.mja.com.au/journal/2012/196/3/what-wrong-medicare-2  

  56. Reece A.S. “Opiate-Related Testicular Stem Cell Niche Toxicopathology”  Accepted International J. High Risk Behaviours and Addiction, Accepted 7th June 2012.  1(2) 86-87.  doi: 10.5812/ijhrba.6522   http://jhrba.com/?page=article&article_id=6522  http://jhrba.com/en/articles/19550.html

  57. Reece A.S. “Restoring the Double Disconnect:  Towards a Conceptual Reinstatement of Opiate Addiction as a High Risk Behaviour”.  Int. J. High Risk Behaviours and Addictions.  Accepted 27/06/2012.   doi: 10.5812/ijhrba.6936  1(2) 47-49. ePub date 25th July 2012. http://jhrba.com/?page=article&article_id=6936  http://jhrba.com/en/articles/19562.html

  58. Kelty E., Nicholls P.K., O’Neil G., Harrison Z., Chan C.T. Symons P., Reece A.S., Hulse G. “The Occurrence of Spontaneous Lymphomas but not adenomas or sarcomas in rats treated with sustained release naltrexone”  Clin. Exp. Pharmacology  2012.  Published 21/04/2012.  2: 105  doi: 10.4172/2161-1459.1000105    http://omicsonline.org/the-occurrence-of-spontaneous-lymphomas-but-not-adenomas-or-sarcomas-in-rats-treated-with-sustained-release-naltrexone-2161-1459.1000105.php?aid=6221

  59. Reece A.S.  Commented Summary on Khademi H. et. al. In BMJ 2012; 314:e2502 doi: 10.1136/bmj.e2502 17/04/2012 “Opium use and mortality in Golestan cohort study.”  Archives of Iranian Medicine (2012); 15 (9): 588-590.  http://www.aimjournal.ir/pdffiles/29_0017Sep2012.pdf   http://www.aimjournal.ir/PDF/29_0017Sep2012.pdf?t=636505300901145704  Published 25/09/2012.

  60. Reece A.S., Hulse G.K.  “Elevation of Central Arterial Stiffness and Vascular Ageing in Opiate Withdrawal: Cross-sectional and Longitudinal Studies”  Cardiovascular Toxicology (2013) 13 (1); 55-67. PMID: 22991174.   doi: 10.1007/s12012-012-9186-7.  http://link.springer.com/article/10.1007%2Fs12012-012-9186-7  

  61. Baxter J., Baker H.M., Reece A.S. "The Use of Cannabis for Medical Purposes."  J Global Drug Policy.  Published 31/12/2013. http://globaldrugpolicy.org/Issues/Vol%207%20Issue%201/The%20Use%20of%20Cannabis%20for%20Medical%20Purposes%20sm.pdf

  62. Reece A.S.  “Epidemiologic and molecular pathophysiology of chronic opioid dependence and the place of naltrexone extended-release formulations in its clinical management”  Substance Abuse: Research and Treatment.  (2012) 6: 115-133. PMID: 23055738.  doi: 10.4137/SART.S9031. Epub 2012 Sep 27.  http://www.la-press.com/epidemiologic-and-molecular-pathophysiology-of-chronic-opioid-dependen-article-a3363-abstract  

  63. Reece A.S. “Absolute and Age Dependent Elevations of Serum Calcium and Phosphate and their Products in Clinical Opiate Dependence”  J Subs. Use,  (2014) 19 (1-2): 125-133.  doi: 10.3109/14659891.2012.754507. ISSN: 1465-9891 http://informahealthcare.com/doi/abs/10.3109/14659891.2012.754507 http://www.tandfonline.com/doi/abs/10.3109/14659891.2012.754507

  64. Reece A.S. “Elevated IGF1 in Clinical Opiate Dependence”  Neuroendocrine Letters, (2013); 34 (1):18-26.   PMID: 23524620.     ISSN: 0172-780X http://www.nel.edu/archive_issues/o/34_1/NEL340113A03_Reece.pdf   

  65. Reece A.S., Hulse G.K.  “Impact of Opioid Pharmacotherapy on Arterial stiffness and Vascular Ageing: Cross-sectional and Longitudinal Studies”.   Cardiovascular Toxicology (2013); 13 (3): 254-266. PMID 23456431.  doi: 10.1007/s12012-013-9204-4  http://link.springer.com/article/10.1007%2Fs12012-013-9204-4  

  66. Reece A.S., Hulse G.K.  “Reduction in Arterial Stiffness and Vascular Age by Naltrexone-Induced Interruption of Opiate Agonism”  BMJ Open (2013) 3(3) pii: e002610.  PMID 23524044    doi: 10.1136/bmjopen-2013-002610  http://bmjopen.bmj.com/content/3/3/e002610.long

  67. Reece A.S, Hulse G.K.  “Lifetime Opiate Exposure as an Independent and Interactive Cardiovascular Risk Factor in Males: A Cross-Sectional Clinical Study”  Vascular Health Risk Management, (2013); 9: 551-561.  .  PMID:  24124373   doi: 10.2147/VHRM.S48030.   Epub 2013 Oct 2.  http://www.dovepress.com/lifetime-opiate-exposure-as-an-independent-and-interactive-cardiovascu-peer-reviewed-article-VHRM

  68. Reece A.S, Hulse G.K.  “Opiate Exposure Increases Arterial Stiffness, Advances Vascular Age and is an Independent Cardiovascular Risk Factor in Females: A Cross-Sectional Clinical Study” World J. Cardiovascular Diseases (2013); ePub 25/07/2013. Vol3: pp361-370. http://dx.doi.org/10.4236/wjcd.2013.35056 .   DOI: 10.4236/wjcd.2013.35056  http://www.scirp.org/journal/PaperInformation.aspx?PaperID=35190; http://file.scirp.org/pdf/WJCD_2013072516143332.pdf

  69. Reece A.S, Hulse G.K.  “Opiate Dependence as an Independent and Interactive Risk Factor for Arterial Stiffness and Cardiovascular Ageing - A Longitudinal Study in Females.” J. Clinical Medical Research  (2013); 5(5): 356-367.  PMID: 23976908.    doi: 10.4021/jocmr1496w. Epub 2013 Aug 5.  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748660/     http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3748660/pdf/jocmr-05-356.pdf    

  70. Reece A.S, Hulse G.K.  "Duration of Opiate Exposure as a Determinant of Arterial Stiffness and Vascular Age in Male Opiate Depende nce: A Longitudinal Study" Journal of Clinical Pharmacy and Therapeutics. (2014); 39 (2): 158-167. PMID: 24329809.  doi: 10.1111/jcpt.12121. Epub 2013 Dec 16  http://onlinelibrary.wiley.com/doi/10.1111/jcpt.12121/abstract;jsessionid=94518B6E81A1EDFAA443AB2FD162D6F1.f01t04  

  71. Reece A.S., Hulse G.K., “Impact of Lifetime Opioid Exposure on Arterial Stiffness and Vascular Age: Cross-sectional and Longitudinal Studies in Men and Women.”  BMJ Open.  Accepted 13/05/2014.  ePub 3/06/2014. 2014;4:e004521.  PMID: 24889849   doi:10.1136/bmjopen-2013-004521  http://bmjopen.bmj.com/content/4/6/e004521.long

  72. Reece A.S., Hulse G.K. “Hypothalamic Pathophysiology in the Neuroimmune, Dysmetabolic and Longevity Complications of Chronic Opiate Dependency”.  J. Forensic Toxicology and Pharmacology, Accepted 28/06/2014.  doi:10.4172/2325-9841.1000126   Published 07/07/2014. http://www.scitechnol.com/hypothalamic-pathophysiology-neuroimmunedysmetabolic-and-longevity-complications-of-chronic-opiate-dependency-e6Bv.php?article_id=2548

  73. Hulse G., Kelty E., Hood D.H., Norman A., Basso M.,  Reece A.S.  “Novel indications for benzodiazepine antagonist flumazenil in GABA mediated pathological conditions of the central nervous system.”  Current Pharmaceutical Design, June 2015.  21(23): .3325-3342. PMID: 26088116. DOI : 10.2174/1381612821666150619092720 ingentaconnect.com/content/ben/cpd/2015/00000021/00000023/art00009?crawler=true  http://www.eurekaselect.com/132297/article

  74. Reece A.S., Hulse G.K.  "Chromothripsis and Epigenomics Complete Causality Criteria for Cannabis- and Addiction- Connected Carcinogenicity, Congenital Toxicity and Heritable Genotoxicity."    Mutation Research (2016); 789: 15-25. PMID: 27208973. DOI:10.1016/j.mrfmmm.2016.05.002 http://www.sciencedirect.com/science/article/pii/S0027510716300574?via%3Dihub

  75. Reece A.S., Norman A., Hulse G.K. "Serum Ionic Dysequilibria in Clinical Opioid Dependence."  Human Experimental Toxicology. 2017: 36 (8) 776-784.  Accepted 19th August 2016. Published 01/01/2017.  PMID: 28703074. DOI: 10.1177/0960327116666649.  http://journals.sagepub.com/doi/abs/10.1177/0960327116666649?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&

  76. Reece A.S., Norman A., Hulse G.K.  "Dramatic Acceleration of Reproductive Aging, Contraction of Biochemical Fecundity and Healthspan-Lifespan Implications of Opioid-Induced Endocrinopathy: FSH/LH Ratio and Other Interrelationships"  Accepted Reproductive Toxicology, 10th September 2016.  2016;  66: 20-30.  Published 20th September 2016.  PubMed ID: 27663472.  DOI: 10.1016/j.reprotox.2016.09.006 http://www.sciencedirect.com/science/article/pii/S0890623816303367 

  77. Reece A.S., Norman A., Hulse G.K.  "Elevation of the ACTH/Cortisol Ratio in Female Opioid Dependent Patients: A Biomarker of Aging and Correlate of Metabolic and Immune Activation"  Accepted Neuroendocrine Letters 2nd October 2016. Vol 37 (4): 325-336.  Published 18/09/2016.  PubMed ID: 27857051. https://www.ncbi.nlm.nih.gov/pubmed/27857051 ; http://www.nel.edu/Current_issue_0.htm

  78. Reece A.S., Norman A., Hulse G.K.  "Cannabis Exposure as an Interactive Cardiovascular Risk Factor and Accelerant of Organismal Ageing – A Longitudinal Study"  6(11):e011891.  Accepted BMJ Open 20th October 2016.  PubMed ID:  27821595.   DOI: http://dx.doi.org/10.1136/bmjopen-2016-011891.   Published BMJ Open 01/11/2016.   http://bmjopen.bmj.com/content/6/11/e011891.full.pdf+html

  79. Reece A.S., Hulse G.K.  Letter in Response to: "Medicinal Cannabis in Australia: The Missing Links" Martin J.H. and Bonomo Y.A., Medical Journal of Australia 205 (9): 425. Published 07.11.2016.  Accepted 28.06.2016. PubMed ID : 27809740  DOI: 10.5694/mja16.00709.   Published 7th November 2016. https://www.mja.com.au/journal/2016/205/9/medicinal-cannabis-australia-missing-links?utm_source=MJA+news+alerts&utm_campaign=c8082025ed-EMAIL_CAMPAIGN_2016_11_03&utm_medium=email&utm_term=0_8c7e70a099-c8082025ed-41326421

  80. Reece A.S., Norman A., Hulse G.K.  "Acceleration of Cardiovascular - Biological Age by Amphetamine Exposure is a Power Function of Chronological Age."  (2017) 9 (1): 30-38.  Accepted by Heart Asia 8th November 2016.  2017, 9 (1): 30-38.  PubMed ID: 28243315. DOI: http://dx.doi.org/10.1136/heartasia-2016-010832  .  http://heartasia.bmj.com/content/9/1/30   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307374/

  81. A.S. Reece.  "Out of the Shadows, Into the Limelight – Sobering Salience of Meta-Analysis of Chronic Periodontitis in Drug Addiction"  Editorial for Addiction Journal.  Accepted 07.02.2017.  2017, 112 (5): 780-781.  PubMed ID: 28378333.   DOI: 10.1111/add.13791 http://onlinelibrary.wiley.com/doi/10.1111/add.13791/abstract;jsessionid=27D50571FD93C32D1C983677FF8C2BAB.f03t01

  82. AS. Reece  "Dying for Love: Perimenopausal Degeneration of Vaginal Microbiome Drives the Chronic Inflammation-Malignant Transformation of Benign Prostatic Hyperplasia to Prostatic Adenocarcinoma"  Accepted by  Medical Hypothesis 13th February 2017. 2017; 101: 44-47.  PubMed ID: 28351489.  DOI: 10.1016/j.mehy.2017.02.006. https://linkinghub.elsevier.com/retrieve/pii/S0306-9877(16)30922-7

  83. Gao X., Wang Y., Lang M.L., Yuan L., Reece A.S., Wang W.  "Contribution of Genetic Polymorphisms and Haplotypes in DRD2, BDNF and Opioid Receptors to Heroin Dependence and Endophenotypes among the Han Chinese."  OMICS: A Journal of Integrative Biology, 2017; 21(7): 404-412.  Accepted 26.05.2017.  PMID: 28692418. dx.doi.org/10.1089/omi.2017.0057.  http://online.liebertpub.com/doi/10.1089/omi.2017.0057 

  84. A.S. Reece, G.K. Hulse.   "What are the Characteristics of Vitamin D Metabolism in Opioid Dependence?  An Exploratory Longitudinal Study in Australian Primary Care"  Accepted in BMJ Open 27th September 2017.  URL: http://bmjopen.bmj.com/content/8/1/e016806   BMJ Open 2018 January 13, 8(1): e016806.  PMID: 29331964.  http://dx.doi.org/10.1136/bmjopen-2017-016806 .

  85. Reece A.S., Wang W., Hulse G.K.  "Pathways from Epigenomics and Glycobiology towards Novel Biomarkers of Addiction and its Radical Cure".  Medical Hypotheses.  Published 17th April 2018.  Vol 116: 10-21.  https://doi.org/10.1016/j.mehy.2018.04.011  .

  86. Reece A.S.  “Known Cannabis Teratogenicity Should be Carefully Considered”  BMJ Rapid Response.  Accepted 06/08/2018.  URL: https://www.bmj.com/content/362/bmj.k3357/rr-0  Chosen as Editors Choice for BMJ 23/10/2018.

  87. Rapid Response to Cardenas A, Villaba A., de Juan Romero C., Pico E., Kyrousi C., Tzika A.C., Tessier-Lavigne M., Ma L., Drukker M., Borrell V.  (2018)  “Evolution of cortical neurogenesis in amniotes is controlled by robo signaling levels.”  Cell 174(3): 590-606.  Published on Cell website. https://www.cell.com/cell/fulltext/S0092-8674(18)30732-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867418307323%3Fshowall%3Dtrue#comments-heading        

  88. Alblooshi H., Al Safar H., Fisher H.F., Cordell H.J., El Khasef A., Al Ghaferi H., Shawky M., Reece S., Hulse G.K., Tay G.K.. A case-control genome wide association study of Substance Use Disorder (SUD) identifies novel variants on chromosome 7p14.1 in patients from the United Arab Emirates (UAE).   American Journal of Medical Genetics Part B: Neuropsychiatric Genetics.  Accepted 21st October 2018.  https://onlinelibrary.wiley.com/doi/10.1002/ajmg.b.32708

  89. Reece A.S., Hulse G.K. “Explaining Contemporary Patterns of Cannabis Teratology”.  Accepted in Clinical Pediatrics 18th January 2019.  https://pdfs.semanticscholar.org/09b5/40b74212f3fc2a5d2e9d4a86a12021d05658.pdf   doi:  10.4172/2572-0775.1000146

  90. Reece A.S. “Cannabis Problematics Include but are not Limited to Pain Management”  JAMA.  Published online 3rd February 2019.  https://jamanetwork.com/journals/jama/fullarticle/2723649 .  doi: doi:10.1001/jama.2019.0077 .

  91. Reece A.S., Hulse G.K.  “Gastroschisis and Autism—Dual Canaries in the Californian Coalmine”  Published online February 6th  2019.  doi: 10.1001/jamasurg.2018.4694    PMID: 30725103 JAMA Surgery https://jamanetwork.com/journals/jamasurgery/article-abstract/2723261

  92. Reece A.S., Hulse G.K. “Effect of Cannabis Legalization on US Autism Incidence and Medium Term Projections.” Clinical Pediatrics: Open Access.  Accepted 27th April 2019.  4(2): 1-17.  https://www.longdom.org/open-access/effect-of-cannabis-legalization-on-us-autism-incidence-and-medium-term-projections.pdf  ePublished 3rd May 2019. DOI: 10.24105/2572-0775.4.154  .

  93. Reece A.S. Rapid Response to “When the Law Fails Patients.” by Hurley R. in British Medical Journal. “Billionaires v Babies.”  Published 10th May 2019.  2019; 365:1980  https://www.bmj.com/content/365/bmj.l1980/rr   doi:  https://doi.org/10.1136/bmj.l1980 

  94. Reece A.S.  Rapid Response to “Why Medical Cannabis is still out of Patient’s Reach.” By Nutt D.  BMJ 2019; 365:1903.  https://www.bmj.com/content/365/bmj.l1903/rr-1.  doi: https://doi.org/10.1136/bmj.l1903.  Published 10th May 2019.

  95. Reece A.S., Hulse G.K. “Epidemiological Associations of Various Substances and Multiple Cannabinoids with Autism in USA”.  Accepted 22nd May 2019.  Clinical Pediatrics: Open Access.  Published 31st May 2019.  https://www.longdom.org/open-access/epidemiological-associations-of-various-substances-and-multiple-cannabinoids-with-autism-in-usa.pdf DOI: 10.24105/2572-0775.4.155

  96. Reece A.S., Hulse G.K.  “Impacts of Cannabinoid Epigenetics on Human Development: Reflections on Murphy et. al. “Cannabinoid Exposure and Altered DNA Methylation in Rat and Human Sperm” Epigenetics 2018; 13: 1208-1221.”  Accepted Epigenetics 14th June 2019. doi: https://doi.org/10.1080/15592294.2019.1633868 .

  97. Reece A.S.    Should We Legalize Cannabis:  “Cannabis Debates and Cannabis Debacles: Serious Downstream Implications of Cannabis Neurotoxicity and Genotoxicity”  British Medical Journal, Rapid Responses,  Published 7th July 2019 https://www.bmj.com/content/366/bmj.l4507/rapid-responses.

  98. Reece A.S. Hulse G.K.  “Cannabis Teratology Explains Current Patterns of Coloradan Congenital Defects: The Contribution of Increased Cannabinoid Exposure to Rising Teratological Trends.”  Clinical Pediatrics.  Published online 9th July 2019.  https://doi.org/10.1177/0009922819861281

  99. Reece A.S., Hulse G.K.,  “Impacts of Cannabinoid Epigenetics on Human Development: Reflections on Murphy et. al. “Cannabinoid Exposure and Altered DNA Methylation in Rat and Human Sperm” Epigenetics 2018; 13: 1208-1221.  13th July 2019.  https://www.tandfonline.com/doi/full/10.1080/15592294.2019.1633868

  100. Reece A.S. “Cannabis Threatens Oocytes, a Non-Renewable National Genomic Resource – and Implications of Prostacyclin Vasodilation and Anti-thrombogenesis”  British Medical Journal Rapid Response.  Accepted 19th July 2019.  https://www.bmj.com/content/366/bmj.l4507/rr-5

  101. Reece A.S. “Unrolling and Unravelling Far-Reaching Implications of Cannabis Use in Pregnancy Study.”  Comment in JAMA Network Online Accepted 31st July 2019.  See Comments Tab. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2738343

  102. Reece A.S., Hulse G.K., Book Chapter for “Heritable Cannabinoid Epidemiology:  Neurotoxicity, Genotoxicity, Teratogenicity and Carcinogenicity”.   Edited in USA.  Springer.  In Press 08/10/2019.  “Linked Rise in Trends of Cannabis Use and Autism Incidence Demonstrated by Close Three Level Geospatiotemporal Relationships, USA, 1990-2011.”

  103. Reece A.S., Hulse G.K., Book Chapter for “Heritable Cannabinoid Epidemiology:  Neurotoxicity, Genotoxicity, Teratogenicity and Carcinogenicity.”   Edited in USA.  34,320 words.  244 Figures.  123 Tables.   464 pages in Manuscript.  Springer.  In Press 08/10/2019.   “Geotemporospatial Analysis of United States 38-44 Congenital Anomalies as a Function of Multiple Cannabinoid- and Substance- Exposure in the Decades of Cannabis Legalization: Phenocopying Thalidomide and Hundred Megabase-Scale Genotoxicity.

  104. Reece A.S., Hulse G.K., “Cannabis Consumption Patterns Parallel the East-West Gradient in Canadian Neural Tube Defect Incidence: An Ecological Study”  Accepted for Global Pediatric Health 20th October 2019.  https://journals.sagepub.com/doi/pdf/10.1177/2333794X19894798 https://doi.org/10.1177/2333794X19894798   Volume 6 (1): 1-12.

  105. Reece A.S., Hulse G.K. “Canadian Cannabis Consumption and Patterns of Congenital Anomalies: An Ecological Geospatial Analysis” .  Accepted in Journal of Addiction Medicine, 6th January 2020.  MS No. JAM-D-00715R3. https://journals.lww.com/journaladdictionmedicine/Abstract/publishahead/Canadian_Cannabis_Consumption_and_Patterns_of.99248.aspx  ePublished 13th March 2020.

  106. Reece A.S., Hulse G.K.  “Response to Lane”.  Rapid Response to Ian A Lane.  “Re: Cannabis exposure as an interactive cardiovascular risk factor and accelerant of organismal ageing: A longitudinal study”  BMJ Open.  ePublished 27th March 2020. https://bmjopen.bmj.com/content/6/11/e011891.responses

  107. Reece A.S., Hulse G.K.  America Addresses Two Epidemics Dataset – Cannabis and Coronavirus and their Interactions: Combined Geospatial and Causal Inference Study Dataset held on Mendeley data repository.  May 2020.  https://data.mendeley.com/drafts/x22mm7bh34

  108. Reece A.S., Hulse G.K.   “Cannabis in Pregnancy – Rejoinder, Exposition and Cautionary Tales.”  Accepted for Publication in Psychiatric Times, 18/07/2020.  ePublished 10/10/2020.  https://www.psychiatrictimes.com/view/cannabis-pregnancy-rejoinder-exposition-cautionary-tales

  109. Reece A.S., Hulse G.K.  “Broad Spectrum Epidemiological Contribution of Cannabis and Other Substances to the Teratological Profile of Northern New South Wales: Geospatial and Causal Inference Analysis”  Published in BMC Pharmacology and Toxicology 13/11//2020.  (2020) 21:75 doi.org/10.1186/s40360-020-00450-1 https://link.springer.com/article/10.1186/s40360-020-00450-1

  110. Reece A.S., Hulse G.K.  “Response to Polocaro and Vettraino”  Accepted in Missouri Medicine 04/10/2020.  https://www.omagdigital.com/publication/?m=11307&i=685331&p=36&pre=1

  111. Reece A.S., Hulse G.K.  “Co-Occurrence Across Time and Space of Drug- and Cannabinoid- Exposure and Adverse Mental Health Outcomes in the National Survey of Drug Use and Health:  Combined Geotemporospatial and Causal Inference Analysis”  Accepted in BMC Public Health 22nd October 2020.  https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-020-09748-5  Published 04/11/2020.  20:1655 https://doi.org/10.1186/s12889-020-09748-5 .

  112. Reece A.S., Hulse G.K.  “Contemporary epidemiology of rising atrial septal defect trends across USA 1991–2016: a combined ecological geospatiotemporal and causal inferential study.”  BMC Pediatrics 2020; 20:539-550.  https://bmcpediatr.biomedcentral.com/track/pdf/10.1186/s12887-020-02431-z.pdf

  113. Reece A.S., Hulse G.K.  “A geospatiotemporal and causal inference epidemiological exploration of substance and cannabinoid exposure as drivers of rising US pediatric cancer rates.”  BMC Cancer. 2021; 21: (1) 197- 230.  https://bmccancer.biomedcentral.com/track/pdf/10.1186/s12885-021-07924-3.pdf .

Professional Summary

Date of Graduation: 1981

Medical School: Sydney University

Teaching Hospital: Concord Hospital

Degree Gained: MBBS

Place in Final Medicine/Surgery Exam: Third

Part 1 FRACS. Passed: October 1983 at first attempt

Pass at Part 1 FRACS.: 80-84%

FRCS. (Ed.) Passed: January 1990 at first attempt

FRCS. (Glas.) Passed: February 1990 at first attempt

MD. (UNSW.) Passed: 1993

FRACGP. Passed: 1994

Associate Professor of Medicine at the University of Western Australia since 2010. 

 

Appointed as Professor of Medicine at the University of Western Australia since 2019.

Full Adjunct Professor of Medicine at Edith Cowan University in Perth from May 2018.

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